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1. Lenz М, Richter Т, Mühlhauser I. The Morbidity and Mortality Associated With Overweight and Obesity in Adulthood. A Systematic Review.DeutschesÄrzteblatt International DtschArzteblInt 2009;106(40):641-8.

2. Бугрова CA, Плохая AA. Лечение ожирения: современные аспекты. РМЖ. 2000;24(9):1140-6.

3. Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognised class of anticarcinogens.J Food Compos Anal. 1992;5:185-97.

4. Pariza MW. Perspective on the safety and effectiveness of conjugated linoleic acid.Am J ClinNutr. 2004;79 (Suppl):1132S-6S.

5. Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice.Lipids. 1997;32:853-8.

6. de Deckere EA, van Amelsvoort JM, McNeill GP, Jones P. Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. Br J Nutr. 1999;82:309-17.

7. Park Y, Storkson JM, Albright KJ, Liu W, Pariza MW. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids. 1999;34:235-41.

8. Gavino VC, Gavino G, Leblanc MJ, Tuchweber B. An isomeric mixture of conjugated linoleic acids but not pure cis-9, trans-11-octadecadienoic acid affects body weight gain and plasma lipids in hamsters. J Nutr. 2000;130:27-9.

9. Pariza MW, Park Y, Cook ME. The biologically active isomers of conjugated linoleic acid.Prog Lipid Res. 2001;40:283-98.

10. Whigham Leah D, Watras Abigail C, Schoeller, Dale A. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J ClinNutr. 2007;85:1203-11.

11. Blankson H, Stakkestad JA, Fagerton H, Thom E, Wadstein J, GudmundsenO. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr. 2000;130:2943-8.

12. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, et al. Conjugated linoleic acid supplementation for 1 у reduces body fat mass in healthy overweight humans. Am J ClinNutr. 2004;79:1118-25.

13. Mougios V, Matsakas A, Petridou A, Ring S, Sagredos A, Melissopoulou A, et al. Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. J Nutr.Biochem. 2001;12:585-94.

14. Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans-metabolic effects. Lipids. 2001;36:773-81.

15. Gaullier JM, Halse J, Høivik HO, Høye K, Syvertsen C, Nurminiemi M, et al. Six months supplementation with conjugated linoleic acid (CLA) induces regional-specific fat mass decreases in overweight and obese. Br J Nutr. 2007;97:50-60.

16. Watras AC, Buchholz AC, Close RN, Zhang Z, Schoeller DA. The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain.Int J Obesity. 2007;31:481-7.

17. Pinkoski C, Chilibeck PD, Candow DG, Esliger D, Ewaschuk JB, Facci M, et al. The effects of conjugated linoleic acid supplementation during resistance training.Med Sci Sports.Exerc. 2006;38:339-48.

18. Berven G, Bye A, Hals O, et al. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol. 2000;102:455-62.

19. Riserus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 2002;25:1516-21.

20. Malpuech-Brugere C, Verboeket-van de Venne WP, Mensink RP, Arnal MA, Morio B, Brandolini M, et al. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obes Res. 2004;12:591-8.

21. Atkinson RL. Conjugated linoleic acid for altering body composition and treating obesity. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, and Nelson GJ, eds. Advances in conjugated linoleic acid research. Vol 1. Champaign, IL: AOCS Press, 1999: 348-353.

22. Kreider RB, Ferreira MP, Greenwood M, Wilson M, Almada AL. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res. 2002;16:325-34.

23. Riserus U, Vessby B, Arnlov J, Basu S. Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J ClinNutr. 2004;80:279-83.

24. Petridou A, Mougios V, Sagredos A. Supplementation with CLA: isomer incorporation into serum lipids and effect on body fat of women. Lipids. 2003;38:805-11.

25. Eyjolfson V, Spriet LL, Dyck DJ. Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med Sci Sports Exerc. 2004;36:814-20.

26. Taylor JS, Williams SR, Rhys R, James P, Frenneaux MP. Conjugated linoleic acid impairs endothelial function. ArteriosclerThrombVasc. Biol. 2006;26:307-12.

27. Lambert EV, Goedecke JH, Bluett K, Heggie K, Claassen A, Rae DE, et al. Conjugated linoleic acid (CLA) vs. high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. Br J Nutr.2007 (in press).

28. Gaullier JM, Halse J, Høye K, Kristiansen K, Fagertun H, Vik H, et al. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr. 2005;135:778-84.

29. Ogden CL, Fryar CD, Carroll MD, Flegal KM. Mean bodyweight, height, and body mass index, United States 1960–2002. Advance data from vital and health statistics; no. 347. Hyattsville, Maryland: National Center for Health Statistics, 2004.

30. Gaullier JM, Berven G, Blankson H, Gudmundsen O. Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids. 2002;37:1019-25.

31. Wang YW, Jones PJ. Conjugated linoleic acid and obesity control: efficacy and mechanisms. Int J ObesRelatMetabDisord. 2004;28:941-55.

32. Riserus U, Basu S, Jovinge S, Fredrikson GN, Arnlov J, Vessby B. Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation. 2002;106:1925-9.

33. Larsen TM, Toubro S, Gudmundsen O, Astrup A. Conjugated linoleic acid supplementation for 1 у does not prevent weight or body fat regain. Am J ClinNutr. 2006;83:606-12.

34. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111:1805-12.

35. Brown DW, Giles WH, Croft JB. White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort. J ClinEpidemiol. 2001;54:316-22.

36. Cracowski JL, Durand T, Bessard G. Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications. Trends Pharmacol Sci. 2002;23:360-6.

37. Musiek ES, Gao L, Milne GL, Han W, Everhart MB, Wang D, et al. Cyclopentenoneisoprostanes inhibit the inflammatory response in macrophages. J Biol Chem. 2005;280:35562-70.

38. Lee KN, Kritchevsky D, Pariza MW. Conjugated linoleic acid and atherosclerosis in rabbits.Atherosclerosis. 1994;108:19-25.

39. Kritchevsky D, Tepper SA, Wright S, Tso P, Czarnecki SK. Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J Am CollNutr. 2000;19:472S-7S.

40. Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson ТА, Nicolosi RJ. Conjugated linoleic acid isomer effects in atherosclerosis: growth and regression of lesions. Lipids. 2004;39:611-6.

41.Whigham LD, Cook EB, Stahl JL, Saban R, Bjorling DE, Pariza MW, et al. CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. Am J PhysiolRegulIntegr Comp Physiol. 2001 ;280:R908-12.

42. Whigham LD, Higbee A, Bjorling DE, Park Y, Pariza MW, Cook ME. Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. Am J PhysiolRegulIntegr Comp Physiol. 2002;282:R1104-12.

43. Jaudszus A, Foerster M, Kroegel C, Wolf I, Jahreis G. Cis-9,trans-11- CLAexerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid. BiochimBiophysActa. 2005;1737:111-8.

44. Yang M, Cook ME. Dietary CLA decreased weight loss and extended survival following the onset of kidney failure in NZB/W F1 mice. Lipids. 2003;38:21-4.

45. Butz D, Cook ME. CLA Modulated immune-induced cachexia after immunization with arthritogenic collagen type II. FASEB J 2002;16:A985.

46. Hontecillas R, Wannemeulher MJ, Zimmerman DR, Hutto DL, Wilson JH, Ahn DU, et al. Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. J Nutr. 2002;132:2019-27.

47. Miller CC, Park Y, Pariza MW, Cook ME. Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. BiochemBiophys Res Commun. 1994;198:1107-12.

48. Graves E, Hitt A, Pariza MW, Cook ME, McCarthy DO. Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. Res Nurs Health. 2005;28:48-55.

49. Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J ClinNutr. 2004;80:887-95.

50. Belury MA. Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Annu Rev Nutr. 2002;22:505-31.

References

1. Lenz M, Richter T, Mühlhauser I. The Morbidity and Mortality Associated With Overweight and Obesity in Adulthood. A Systematic Review.DeutschesÄrzteblatt International DtschArzteblInt 2009;106(40):641-8.

2. Butrova SA, Plokhaya AA. Lecheniyeozhireniya: sovremennyyeaspekty. RMZh. 2000;24(9):1140-6. Russian.

3. Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognised class of anticarcinogens.J Food Compos Anal. 1992;5:185-97.

4. Pariza MW. Perspective on the safety and effectiveness of conjugated linoleic acid.Am J ClinNutr. 2004;79 (Suppl):1132S-6S.

5. Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice.Lipids.1997; 32:853-8.

6. de Deckere EA, van Amelsvoort JM, McNeill GP, Jones P. Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. Br J Nutr. 1999;82:309-17.

7. Park Y, Storkson JM, Albright KJ, Liu W, Pariza MW. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids. 1999;34:235-41.

8. Gavino VC, Gavino G, Leblanc MJ, Tuchweber B. An isomeric mixture of conjugated linoleic acids but not pure cis-9, trans-11 -octadecadienoic acid affects body weight gain and plasma lipids in hamsters. J Nutr. 2000;130:27-9.

9. Pariza MW, Park Y, Cook ME. The biologically active isomers of conjugated linoleic acid.Prog Lipid Res. 2001;40:283-98.

10. Whigham Leah D, Watras Abigail C, Schoeller, Dale A. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J ClinNutr. 2007;85:1203-11.

11. Blankson H, Stakkestad JA, Fagerton H, Thorn E, Wadstein J, Gudmundsen 0. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr. 2000;130:2943-8.

12. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, et al. Conjugated linoleic acid supplementation for 1 у reduces body fat mass in healthy overweight humans. Am J ClinNutr. 2004;79:1118-25.

13. Mougios V, Matsakas A, Petridou A, Ring S, Sagredos A, Melissopoulou A, et al. Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. J Nutr.Biochem. 2001;12:585-94.

14. Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans-metabolic effects. Lipids. 2001;36:773-81.

15. Gaullier JM, Halse J, Høivik HO, Høye K, Syvertsen C, Nurminiemi M, et al. Six months supplementation with conjugated linoleic acid (CLA) induces regional-specific fat mass decreases in overweight and obese. Br J Nutr. 2007;97:50-60.

16. Watras AC, Buchholz AC, Close RN, Zhang Z, Schoeller DA. The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain.Int J Obesity. 2007;31:481-7.

17. Pinkoski C, Chilibeck PD, Candow DG, Esliger D, Ewaschuk JB, Facci M, et al. The effects of conjugated linoleic acid supplementation during resistance training.Med Sci Sports.Exerc. 2006;38:339-48.

18. Berven G, Bye A, Hals O, et al. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol. 2000;102:455-62.

19. Riserus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 2002;25:1516-21.

20. Malpuech-Brugere C, Verboeket-van de Venne WP, Mensink RP, Arnal MA, Morio B, Brandolini M, et al. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obes Res. 2004;12:591-8.

21. Atkinson RL. Conjugated linoleic acid for altering body composition and treating obesity. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, and Nelson GJ, eds. Advances in conjugated linoleic acid research. Vol 1. Champaign, IL: AOCS Press, 1999: 348-353.

22. Kreider RB, Ferreira MP, Greenwood M, Wilson M, Almada AL. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res. 2002;16:325-34.

23. Riserus U, Vessby B, Arnlov J, Basu S. Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J ClinNutr. 2004;80:279-83.

24. Petridou A, Mougios V, Sagredos A. Supplementation with CLA: isomer incorporation into serum lipids and effect on body fat of women. Lipids. 2003;38:805-11.

25. Eyjolfson V, Spriet LL, Dyck DJ. Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med Sci Sports Exerc.2004; 36:814-20.

26. Taylor JS, Williams SR, Rhys R, James P, Frenneaux MP. Conjugated linoleic acid impairs endothelial function. ArteriosclerThromb Vase.Biol. 2006; 26:307-12.

27. Lambert EV, Goedecke JH, Bluett K, Heggie K, Claassen A, Rae DE, et al. Conjugated linoleic acid (CLA) vs. high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals. Br J Nutr.2007 (in press).

28. Gaullier JM, Halse J, Høye K, Kristiansen K, Fagertun H, Vik H, et al. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr. 2005;135:778-84.

29. Ogden CL, Fryar CD, Carroll MD, Flegal KM. Mean bodyweight, height, and body mass index, United States 1960–2002. Advance data from vital and health statistics; no. 347. Hyattsville, Maryland: National Center for Health Statistics, 2004.

30. Gaullier JM, Berven G, Blankson H, Gudmundsen O. Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids. 2002;37:1019-25.

31. Wang YW, Jones PJ. Conjugated linoleic acid and obesity control: efficacy and mechanisms. Int J ObesRelatMetabDisord. 2004;28:941-55.

32. Riserus U, Basu S, Jovinge S, Fredrikson GN, Arnlov J, Vessby B. Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation. 2002;106:1925-9.

33. Larsen TM, Toubro S, Gudmundsen O, Astrup A. Conjugated linoleic acid supplementation for 1 у does not prevent weight or body fat regain. Am J ClinNutr. 2006;83:606-12.

34. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111:1805-12.

35. Brown DW, Giles WH, Croft JB. White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort. J ClinEpidemiol. 2001;54:316-22.

36. Cracowski JL, Durand T, Bessard G. Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications. Trends Pharmacol Sci. 2002;23:360-6.

37. Musiek ES, Gao L, Milne GL, Han W, Everhart MB, Wang D, et al. Cyclopentenoneisoprostanes inhibit the inflammatory response in macrophages. J Biol Chem. 2005;280:35562-70.

38. Lee KN, Kritchevsky D, Pariza MW. Conjugated linoleic acid and atherosclerosis in rabbits.Atherosclerosis. 1994;108:19-25.

39. Kritchevsky D, Tepper SA, Wright S, Tso P, Czarnecki SK. Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J Am CollNutr. 2000;19:472S-7S.

40. Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson ТА, Nicolosi RJ. Conjugated linoleic acid isomer effects in atherosclerosis: growth and regression of lesions. Lipids. 2004;39:611-6.

41. Whigham LD, Cook EB, Stahl JL, Saban R, Bjorling DE, Pariza MW, et al. CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. Am J PhysiolRegulIntegr Comp Physiol. 2001 ;280:R908-12.

42. Whigham LD, Higbee A, Bjorling DE, Park Y, Pariza MW, Cook ME. Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. Am J PhysiolRegulIntegr Comp Physiol. 2002;282:R1104-12.

43. Jaudszus A, Foerster M, Kroegel C, Wolf I, Jahreis G. Cis-9,trans-11-CLAexerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid. BiochimBiophysActa. 2005;1737:111-8.

44. Yang M, Cook ME. Dietary CLA decreased weight loss and extended survival following the onset of kidney failure in NZB/W F1 mice. Lipids. 2003;38:21-4.

45. Butz D, Cook ME. CLA Modulated immune-induced cachexia after immunization with arthritogenic collagen type II. FASEB J 2002;16:A985.

46. Hontecillas R, Wannemeulher MJ, Zimmerman DR, Hutto DL, Wilson JH, Ahn DU, et al. Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. J Nutr. 2002;132:2019-27.

47. Miller CC, Park Y, Pariza MW, Cook ME. Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. BiochemBiophysResCommun. 1994;198:1107-12.

48. Graves E, Hitt A, Pariza MW, Cook ME, McCarthy DO. Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. Res Nurs Health. 2005;28:48-55.

49. Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J ClinNutr. 2004;80:887-95.

50. Belury MA. Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. AnnuRevNutr. 2002;22:505-31.

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